Advancing best practices in cryogenic cold chain solutions.
Advancing best practices in cryogenic cold chain solutions

Sharing fundamental research, education, discussion and best practices for cryogenic cold chain management, biobanking, glass transition; biosample storage, preparation, planning and recovery and associated issues.


John Fink

John Fink is marketing manager for cryogenic solutions at Brooks Life Science Systems, the global leader in automated cold-chain sample management for drug discovery and biostorage applications and a division of Brooks Automation, Inc. if you have any questions or ideas for future blog posts.

What is the potential cost of non-reproducible scientific research?

July 23, 2015

In order for scientific breakthroughs to be effective, they must be reproducible.  This isn’t always simple though, something I learned early on in grade school science labs…

At the professional level however, there are reported instances where published research was not able to be reproduced by other scientists. Some estimate this irreproducibility as high as 50%.  What is the cost of this irreproducible research?  According to NPR’s “All Things Considered”, experts estimate the potential cost to be as high as $28 billion (that’s billion with a “B”). And although, some believe this dollar value is sensationalized, there is always room for improvement.  In fact, GBSI is pushing for standardizations for cellular research and subsequent publications.

How does this relate to cold chain management?

Cold space storage of samples or product materials is a function with a significant quality aspect, because any variability in storage is carried forward to all future use of the stored material – any changes are irreversible.

The old adage garbage-in, garbage-out holds true for cryogenic storage, what you put into the freezer is what you will get back out.  However, if your cold chain management standards are not consistent and of a high quality you may have gold-in, garbage-out and thus, non‑reproducible research.