Advancing best practices in cryogenic cold chain solutions.
Advancing best practices in cryogenic cold chain solutions

Sharing fundamental research, education, discussion and best practices for cryogenic cold chain management, biobanking, glass transition; biosample storage, preparation, planning and recovery and associated issues.


John Fink

John Fink is marketing manager for cryogenic solutions at Brooks Life Science Systems, the global leader in automated cold-chain sample management for drug discovery and biostorage applications and a division of Brooks Automation, Inc. if you have any questions or ideas for future blog posts.

Stepping Toward Cryo Automation at the Mayo Clinic

June 27, 2016

People often think the path to automation is a very steep incline costing a lot of time and money, but it doesn’t have to be.

In this poster from the Mayo Clinic they describe how they are moving a legacy cryo vial collection towards automation through small steps at much less cost and complexity than if done in one big step.

Their steps to automation are:

  1. Purchase an Automation-Ready LN2 Freezer (able to be upgraded to full automation).
    • Much less expensive than purchasing full automation up front.
  2. The legacy collection is all hand written IDs.  Therefore, they are moving legacy unbarcoded vials into barcoded cryoboxes that will enable tracking in LIMS going forward.
    • Moving legacy samples into barcoded vials would thaw the samples.
  3. These new barcoded cryoboxes will go into the Automation Ready LN2 Freezer and the inventory can be recorded.
  4. Going forward, new samples will be stored in barcoded vials and cryoboxes which will be stored in the Automation Ready LN2 Freezer.
  5. When sample demand increases they plan to upgrade their Automation Ready LN2 Freezer to a full BioStore III Cryo storage system.


For labs interested in cryo automation, it is good to know you can step into it over time rather than in one giant leap.